Prime Editing and CRISPR Market: Current Analysis and Forecast (2021-2027)

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Emphasis on Service (Cell Line Engineering, Genome Regulation, Gene Editing, Gene-Modified Cell Therapy); Application (Biomedical Research & Therapy, Agricultural Research, Others); End-User (Academic Institutes, Biotechnology & Pharma Companies, Contract Research Organizations); and Region & Country.

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UMUPHE2101

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Research Methodology

Report Description

RD_Prime Editing and CRISPR Market – Current Scenario and Forecast (2021-2027)

Prime Editing and CRISPR Market is expected to exceed the market valuation of more than US$ XX billion in 2027 and is expected to grow at a significant CAGR of 24% during the forecast period (2021-2027). The recent discovery of the clustered regularly interspaced short palindromic repeats (CRISPR)- Cas system is revolutionizing the field of medicine and molecular biology. CRISPR-mediated genome editing is a process that generates a Cas9-induced double-strand break which is then repaired using the non-homologous end joining (NHEJ) mechanism or homology-directed repair (HDR). HDR is not as efficient and has high rates of indel mutations which overall nullifies the potential benefits of the repairing mutations. CRISPR/Cas-mediated single-base-pair editing systems have recently managed to bypass these limitations. There are two classes of DNA base editors (BEs): the cytosine base editors (CBEs) and adenine base editors (ABEs. These Bes install all the four transition mutations. The latest addition to the CRISPR genome-engineering toolkit is the prime editors (PEs). These represent a novel approach and can achieve donor-free precise DNA editing to also small insertion and deletion mutations in addition to transition and transversion mutation. DNA base-editing and prime-editing tools collectively enable precise nucleotide substitutions in a programmable manner without the need for a donor template. This tool can correct disease-causing mutations in the human genome. By targeting the four transition mutations, over 25% of the human pathogenic SNPs can be corrected and prime editing can correct up to 89% of the known genetic variants of human diseases.

Key factors influencing the Prime Editing and CRISPR market growth include the increasing demand for gene manipulation technology, increasing funding of the government and private sectors, increasing investments in R&D, and increasing prevalence of genetic diseases. In January 2020, the Genome India Project (GIP) initiated by the Department of Biotechnology in India aims to collect 10,000 genetic samples from its citizens and develop a reference genome.

Prime Editing for SCD, Tay Sachs and Prion Disease Efficiency and Indels (%), 2019

Beam Therapeutics, CRISPR Therapeutics, GenScript Biotech, Horizon Discovery, Integrated DNA Technologies (IDT), Intellia Therapeutics Inc., Inscripta, Precision Bioscience, Sangoma Therapeutics, and Synthego Corporation are some of the prominent players operating in the Prime Editing and CRISPR market. Several M&As along with partnerships have been undertaken by these players to facilitate customers with hi-tech and innovative products/technologies.

Insights Presented in the Report

“Amongst Service, Gene Editing segment holds the major share”

Based on service, the prime editing and CRISPR market is segmented into Cell Line Engineering, Genome Regulation, Gene Editing, and Gene-Modified Cell Therapy. Amongst services, the gene-editing segment of the market was valued at US$ XX billion in 2020 and is likely to reach US$ XX billion by 2027 growing at a CAGR of XX% from 2021-2027. This is due to the growing demand for gene therapy for targeted drug discovery processes and advancing research in genome-based diseases. The gene-modified cell therapy segment is also expected to witness lucrative growth during the forecast period, due to the increasing prevalence of chronic diseases and the surge in stem cell and genomic research.

“Amongst Application, Agricultural Research segment holds the major share”

Based on application, the prime editing and CRISPR market is segmented into Biomedical Research & Therapy, Agricultural Research, and Others. Amongst applications, agricultural research accounted for a market valuation of US$ XX billion in 2020 and is expected to reach US$ XX billion by the year 2027, at a CAGR of XX% over the analyzed period. This is owing to the rising demand for genetically mutated crops and increasing funding in biotechnology organizations. Another segment expected to witness a good market growth is the biomedical research and therapy segment owing to the increasing prevalence of sickle cell anemia disease and the surge in gene editing adoption.

“Amongst End-User, Biotechnology & Pharma Companies segment holds the major share”

Based on end-user, the prime editing and CRISPR market is segmented into Academic Institutes, Biotechnology & Pharma Companies, and Contract Research Organizations. Academic institutes are further segmented into Biomedical Research & Therapy, Agricultural Research, and Others. Biotechnology & Pharma Companies are further segmented into Biomedical Research & Therapy, Agricultural Research, and Others. Lastly, Contract Research Organizations are further segmented into Biomedical Research & Therapy, Agricultural Research, and Others. The biotechnology & pharma companies segment generated revenue of US$ XX billion in 2020 and is expected to grow at a CAGR of XX% during the forecast period to reach a market valuation of US$ XX billion by 2027F. This is due to the surge in chronic and genetic diseases and the increasing demand for monoclonal antibodies.

“North America represents one of the largest markets of Prime Editing and CRISPR market”

For a better understanding of the market dynamics of the Prime Editing and CRISPR market, a detailed analysis was conducted for different regions across the globe including North America (the U.S, Canada, and the Rest of North America), Europe (Germany, France, Italy, United Kingdom, Spain, and Rest of Europe), Asia-Pacific (China, Japan, India, Australia, and Rest of APAC) and Rest of the World. North America dominated the market and grabbed around XX% market share owing to the increasing prevalence of genetic diseases and the availability of faster and better CRISPR tools.

Reasons to buy this report:

  • The study includes market sizing and forecasting analysis validated by authenticated key industry experts
  • The report presents a quick review of overall industry performance at one glance
  • The report covers an in-depth analysis of prominent industry peers with a primary focus on key business financials, product portfolio, expansion strategies, and recent developments
  • Detailed examination of drivers, restraints, key trends, and opportunities prevailing in the industry
  • The study comprehensively covers the market across different segments
  • Deep dive regional level analysis of the industry

Customization Options:

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1.1. Market Definitions
1.2. Objective of the Study
1.3. Limitation
1.4. Stake Holders
1.5. Currency Used in Report
1.6. Scope of the Prime Editing and CRISPR Market Study

2.1. Research Methodology for the Prime Editing and CRISPR Market
   2.1.1. Main Objective of the Prime Editing and CRISPR Market

INDUSTRY PERFORMANCE
EXECUTIVE SUMMARY

5.1 Introduction
5.2 Market Dynamics
     5.2.1 Market Trends & Drivers
        5.2.1.1 Stringent Government Regulations on GHG emission
        5.2.1.2 Increasing Demand of Composites in Hybrid and Electric Vehicles
        5.2.1.3 Crashworthiness Capability
     5.2.2 Market Restraints
        5.2.2.1 Lack of Innovation & Advancements in Emerging Countries
        5.2.2.2 High Cost of the Raw Materials
     5.2.3 Market Opportunities
        5.2.3.1 Growing Scope of Hybrid Composite Materials
        5.2.3.2 Increase in partnerships Between OEMs and Composite Manufacturers
        5.2.3.3 Growth in Developing Countries

6.1. Cell Line Engineering
6.2. Genome Regulation
6.3. Gene Editing
6.4. Gene-Modified Cell Therapy

7.1. Biomedical Research & Therapy
7.2. Agricultural Research
7.3. Others

8.1. Academic Institutes
   8.1.1. Biomedical Research & Therapy
   8.1.2. Agricultural Research
   8.1.3. Others
8.2 Biotechnology & Pharma Companies
   8.2.1. Biomedical Research & Therapy
   8.2.2. Agricultural Research
   8.2.3. Others
8.3 Contract Research Organizations
   8.3.1. Biomedical Research & Therapy
   8.3.2. Agricultural Research
   8.3.3. Others

9.1. NORTH AMERICA PRIME EDITING AND CRISPR MARKET
   9.1.1. United States of America
   9.1.2. Canada
   9.1.3. Rest of North America
9.2. EUROPE PRIME EDITING AND CRISPR MARKET
   9.2.1. United Kingdom
   9.2.2. Germany
   9.2.3. France
   9.2.4. Spain
   9.2.5. Italy
   9.2.6. Rest of Europe
9.3. ASIA-PACIFIC PRIME EDITING AND CRISPR MARKET
   9.3.1. China
   9.3.2. Japan
   9.3.3. India
   9.3.4. Australia
   9.3.5. Rest of Asia-Pacific
9.4. REST OF THE WORLD PRIME EDITING AND CRISPR MARKET

LEGAL AND REGULATORY FRAMEWORK

11.1. Demand Side Analysis
11.2. Supply Side Analysis
   11.2.1. Top Product Launches
   11.2.2. Top Business Partnerships
   11.2.3. Top Business Expansions, Investments and Divestitures
   11.2.4. Top Merger and Acquisitions

VALUE CHAIN ANALYSIS

PRIME EDITING AND CRISPR MARKET TRENDS & INSIGHTS

14.1. Drivers
14.2. Challenges
14.3. Impact Analysis
14.4. Opportunity

15.1. Market Share of Prime Editing and CRISPR Market Share, by Company 2020

16.1. Beam Therapeutics
16.2. CRISPR Therapeutics
16.3. GenScript Biotech
16.4. Horizon Discovery
16.5. Integrated DNA Technologies (IDT)
16.6. Intellia Therapeutics Inc.
16.7. Inscripta
16.8. Precision Bioscience
16.9. Sangoma Therapeutics
16.10. Synthego Corporation

DISCLAIMER

Research Methodology

Research Methodology for the Prime Editing and CRISPR Market Analysis (2021-2027)

Analyzing the historical market, estimation of the current market, and forecasting the future market of the Prime Editing and CRISPR market were the three major steps undertaken to create and analyze the adoption of Prime Editing and CRISPR in major regions globally. Exhaustive secondary research was conducted to collect the historical market numbers and estimate the current market size. Secondly, to validate these insights, numerous findings and assumptions were taken into consideration. Moreover, exhaustive primary interviews were also conducted, with industry experts across the value chain of the Prime Editing and CRISPR market. Post assumption and validation of market numbers through primary interviews, we employed a top-down/bottom-up approach to forecasting the complete market size. Thereafter, market breakdown and data triangulation methods were adopted to estimate and analyze the market size of segments and sub-segments the industry pertains to. Detailed methodology is explained below:

Analysis of Historical Market Size

Step 1: In-Depth Study of Secondary Sources:

Detail secondary study was conducted to obtain the historical market size of the Prime Editing and CRISPR through company internal sources such as annual reports & financial statements, performance presentations, press releases, etc., and external sources including journals, news & articles, government publications, competitor publications, sector reports, third-party database, and other credible publications.

Step 2: Market Segmentation:

After obtaining the historical market size of the Prime Editing and CRISPR market, we conducted a detailed secondary analysis to gather historical market insights and share for different segments & sub-segments for major regions. Major segments included in the report as service, application, and end-user. Further country-level analyses were conducted to evaluate the overall adoption of Prime Editing and CRISPR in that region.

Step 3: Factor Analysis:

After acquiring the historical market size of different segments and sub-segments, we conducted a detailed factor analysis to estimate the current market size of Prime Editing and CRISPR. Further, we conducted factor analysis using dependent and independent variables such as the increase in demand for targeted gene technology and the increasing prevalence of genetic-based diseases. A thorough analysis was conducted for demand and supply-side scenarios considering top partnerships, merger and acquisition, business expansion, and product launches in the Prime Editing and CRISPR sector across the globe.

Current Market Size Estimate & Forecast

Current Market Sizing: Based on actionable insights from the above 3 steps, we arrived at the current market size, key players in the Prime Editing and CRISPR market, and market shares of the segments. All the required percentage shares split, and market breakdowns were determined using the above-mentioned secondary approach and were verified through primary interviews.

Estimation & Forecasting: For market estimation and forecast, weights were assigned to different factors including drivers & trends, restraints, and opportunities available for the stakeholders. After analyzing these factors, relevant forecasting techniques i.e., top-down/bottom-up approach was applied to arrive at the market forecast about 2027 for different segments and subsegments across the major markets globally. The research methodology adopted to estimate the market size encompasses:

  • The industry’s market size, in terms of value (US$) and the adoption rate of Prime Editing and CRISPR across the major markets domestically
  • All percentage shares, splits, and breakdowns of market segments and sub-segments
  • Key players in the Prime Editing and CRISPR market in terms of products offered. Also, the growth strategies adopted by these players to compete in the fast-growing market

Market Size and Share Validation

Primary Research: In-depth interviews were conducted with the Key Opinion Leaders (KOLs) including Top Level Executives (CXO/VPs, Sales Head, Marketing Head, Operational Head, and Regional Head, Country Head, etc.) across major regions. Primary research findings were then summarized, and statistical analysis was performed to prove the stated hypothesis. Inputs from primary research were consolidated with secondary findings, hence turning information into actionable insights.

Split of Primary Participants in Different Regions

Market Engineering

Data triangulation technique was employed to complete the overall market estimation and to arrive at precise statistical numbers of each segment and sub-segment of the Prime Editing and CRISPR market. Data was split into several segments & sub-segments post studying various parameters and trends in the areas of type and their type of the Prime Editing and CRISPR market.

The main objective of the Prime Editing and CRISPR Market Study

The current & future market trends of Prime Editing and CRISPR were pinpointed in the study. Investors can gain strategic insights to base their discretion for investments from the qualitative and quantitative analysis performed in the study. Current and future market trends were determined the overall attractiveness of the market at a regional level, providing a platform for the industrial participant to exploit the untapped market to benefit as a first-mover advantage. Other quantitative goals of the studies include:

  • Analyze the current and forecast market size of Prime Editing and CRISPR in terms of value (US$). Also, analyze the current and forecast market size of different segments and sub-segments
  • Segments in the study include areas of type and their subtypes
  • Define and analysis of the regulatory framework for the Prime Editing and CRISPR industry
  • Analyze the value chain involved with the presence of various intermediaries, along with analyzing customer and competitor behaviors of the industry
  • Analyze the current and forecast market size of the Prime Editing and CRISPR market for the major region
  • Major regions studied in the report include North America (the U.S, Canada, and Rest of North America), Europe (Germany, United Kingdom, France, Spain, Italy, and Rest of Europe), Asia-Pacific (China, Japan, India, Australia, and Others), and the Rest of the World
  • Company profiles of the Prime Editing and CRISPR market and the growth strategies adopted by the market players to sustain in the fast-growing market

Deep dive regional level analysis of the industry