NGS Sample Preparation Market: Current Analysis and Forecast (2021-2027)

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Global NGS Sample Preparation Market is anticipated to grow with an elevated CAGR of around 15% over the forecast period (2021-2027). Next-generation sequencing (NGS) is a technology used to determine the RNA or DNA sequence to study genetic variation associated with various types of diseases or other biological phenomena. With advancements in sequencing technologies and constant innovations, the protocols for sample preparation have been standardized.

The NGS sample preparation market has been growing on account of various factors including the growing emphasis on NGS-based diagnostics and surging incidences of cancer across the globe. For instance, the number of cancer cases in the US will increase 49% each year, from 1,534,500 in 2015 to 2,286,300 in 2050, with the largest percentage increase among adults aged ≥75 years, as per the predictions by CDC. This exponential increase in cancer prevalence has created a buzz among biotechnology and pharmaceutical companies for investing in the development of effective and reliable diagnostic tools based on the NGS.

Furthermore, promulgating strategic alliances among industry players and growing advancement in NGS technologies which can be used in different areas of biomedical, basic research and agriculture are other factors that are significantly driving the NGS sample preparation market globally. For example, in June 2020, 10x Genomics, Inc. and Merck collaborated for providing impactful linking of two innovative technologies: single-cell transcriptomics and pooled CRISPR screening to the researchers which will provide more detailed information to them for understanding the relationship between specific genes and disease. 

Becton, Dickinson and Company, Thermo Fisher Scientific, QIAGEN N.V., Agilent Technologies, Inc., F. Hoffmann-La Roche Ltd., Integrated DNA Technologies, Inc., Beckman Coulter, Pacific Biosciences of California, Promega Corporation, are some of the prominent players operating in the NGS sample preparation market. Several M&As along with partnerships have been undertaken by these players to facilitate customers with NGS sample preparation products.

Insights Presented in the Report

“Amongst Product, reagents & consumables segment holds the major share”

Based on product, the NGS sample preparation market is segmented into workstations and reagents & consumables. In 2020, the reagents & consumables segment accounted for a significant market share, and it is projected that it will exhibit considerable growth during the forecast period owing to the rising number of sequencing procedures and the launch of new and advanced consumables. In addition, the growing adoption of next-generation sequencing because of the availability of research grants, decreasing cost of sequencing, and increasing application of NGS in various fields are also contributing to the growth of this segment.

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“Amongst Library Preparation, DNA segment holds the major share”

Based on library preparation, the NGS sample preparation market is divided into DNA, RNA, target enrichment, and quality control. The DNA segment accounted for a significant market share in 2020 and it is estimated that it will exhibit considerable growth during the forecast period as DNA is most commonly used for sequence profiling in the next-generation sequencing procedures. Library preparation allows DNA to adhere to the sequencing flowcell and allows the sample to be identified.

“Amongst Technology, sequencing by synthesis segment holds the major share”

Based on technology, the market is fragmented into sequencing by synthesis, ion semiconductor sequencing, nanopore sequencing, and other technologies. In 2020, the sequencing by synthesis (SBS) technology segment grabbed a considerable market share, and it is expected to grow at a significant CAGR during the forecast. This segment is expected to grow as Illumina sequencing technology, sequencing by synthesis (SBS) is widely adopted NGS technology across the world and responsible for generating more than 90% of the world’s sequencing data. Further, the increase in the availability of NGS platforms based on SBS is driving the growth of the segment.

“Amongst Application, disease diagnostics segment holds the major share”

Based on application, the NGS sample preparation market is divided into disease diagnostics, drug discovery, and agriculture and animal research. The disease diagnostics segment occupied the major share of the NGS sample preparation market in 2020 and it is expected to grow with substantial CAGR in the upcoming years. The growth of this segment is attributed to the growing prevalence of various diseases such as cancer, infectious, and other rare diseases. For instance, according to the World Health Organization, more than 13 million people die from infectious diseases each year. Further, in some developing countries, it leads to 1 in 2 deaths annually.

“Amongst End-Users, academic institutes and research centers segment holds the major share”

Based on end-users, the market is fragmented into academic institutes and research centers, hospitals & clinics, pharmaceutical & biotechnology companies, and other end-users. In 2020, the academic institutes & research centers segment grabbed a considerable market share, and it is expected to grow at a significant CAGR during the forecast. This is because of the increasing adoption of NGS in cancer research for identifying new cancer-related genes and to study modifications that may contribute to tumorigenesis. In addition, Promulgating strategic alliances between NGS market players and academic & research centers and the availability of funds for genomics R&D across the globe are also some of the major factors contributing to the growth of this segment.

“North America represents one of the largest markets of NGS sample preparation market”

For a better understanding of the market dynamics of the NGS sample preparation market, a detailed analysis was conducted for different regions across the globe including North America (U.S, Canada, and Rest of North America), Europe (Germany, France, Spain, United Kingdom, Italy, and Rest of Europe), Asia-Pacific (China, India, Australia, Japan, and Rest of APAC), Rest of World has been conducted. North America constitutes a major market for the NGS sample preparation market industry and generated revenue of USD XX Million in 2020 owing to strong healthcare infrastructure and growing adoption of advanced technological solutions in the healthcare industry in the region.

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• The study includes market sizing and forecasting analysis validated by authenticated key industry experts
• The report presents a quick review of overall industry performance at one glance
• The report covers an in-depth analysis of prominent industry peers with a primary focus on key business financials, product portfolio, expansion strategies, and recent developments
• Detailed examination of drivers, restraints, key trends, and opportunities prevailing in the industry
• The study comprehensively covers the market across different segments
• Deep dive regional level analysis of the industry

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Research Methodology

Analyzing the historical market, estimation of the current market, and forecasting the future market of the global NGS sample preparation market were the three major steps undertaken to create and analyze the adoption of NGS sample preparation in major regions globally. Exhaustive secondary research was conducted to collect the historical market numbers and estimate the current market size. Secondly, to validate these insights, numerous findings and assumptions were taken into consideration. Moreover, exhaustive primary interviews were also conducted, with industry experts across the value chain of the global NGS sample preparation market. Post assumption and validation of market numbers through primary interviews, we employed a top-down/bottom-up approach to forecasting the complete market size. Thereafter, market breakdown and data triangulation methods were adopted to estimate and analyze the market size of segments and sub-segments the industry pertains to. Detailed methodology is explained below:

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Analysis of Historical Market Size

Step 1: In-Depth Study of Secondary Sources:

Detail secondary study was conducted to obtain the historical market size of the NGS sample preparation  through company internal sources such as annual report & financial statements, performance presentations, press releases, etc., and external sources including journals, news & articles, government publications, competitor publications, sector reports, third-party database, and other credible publications.

Step 2: Market Segmentation:

After obtaining the historical market size of the NGS sample preparation market, we conducted a detailed secondary analysis to gather historical market insights and share for different segments & sub-segments for major regions. Major segments included in the report as technology, product, library preparation, application, and end-users. Further country-level analyses were conducted to evaluate the overall adoption of NGS sample preparation across the globe.

Step 3: Factor Analysis:

After acquiring the historical market size of different segments and sub-segments, we conducted a detailed factor analysis to estimate the current market size of the NGS sample preparation. Further, we conducted factor analysis using dependent and independent variables such as reduced cost of sequencing and technological advancements in NGS platforms. A thorough analysis was conducted for demand and supply-side scenarios considering top partnerships, merger and acquisition, business expansion, and product launches in the NGS sample preparation sector across the globe.

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Current Market Size Estimate & Forecast

Current Market Sizing: Based on actionable insights from the above 3 steps, we arrived at the current market size, key players in the NGS sample preparation market, and market shares of the segments. All the required percentage shares split, and market breakdowns were determined using the above-mentioned secondary approach and were verified through primary interviews.

Estimation & Forecasting: For market estimation and forecast, weights were assigned to different factors including drivers & trends, restraints, and opportunities available for the stakeholders. After analyzing these factors, relevant forecasting techniques i.e., top-down/bottom-up approach was applied to arrive at the market forecast about 2027 for different segments and subsegments across the major markets globally. The research methodology adopted to estimate the market size encompasses:

• The industry’s market size, in terms of value (US$) and the adoption rate of NGS sample preparation across the major markets domestically
• All percentage shares, splits, and breakdowns of market segments and sub-segments
• Key players in the NGS sample preparation market in terms of products offered. Also, the growth strategies adopted by these players to compete in the fast-growing market

Market Size and Share Validation

Primary Research: In-depth interviews were conducted with the Key Opinion Leaders (KOLs) including Top Level Executives (CXO/VPs, Sales Head, Marketing Head, Operational Head, and Regional Head, Country Head, etc.) across major regions. Primary research findings were then summarized, and statistical analysis was performed to prove the stated hypothesis. Inputs from primary research were consolidated with secondary findings, hence turning information into actionable insights.

Split of Primary Participants in Different Regions

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Market Engineering

Data triangulation technique was employed to complete the overall market estimation and to arrive at precise statistical numbers of each segment and sub-segment of the NGS sample preparation market. Data was split into several segments & sub-segments post studying various parameters and trends in the areas of technology, library preparation, product, application, and end-users of the NGS sample preparation market.

The main objective of the NGS sample preparation  Market Study

The current & future market trends of NGS sample preparation were pinpointed in the study. Investors can gain strategic insights to base their discretion for investments from the qualitative and quantitative analysis performed in the study. Current and future market trends were determined the overall attractiveness of the market at a regional level, providing a platform for the industrial participant to exploit the untapped market to benefit as a first-mover advantage. Other quantitative goals of the studies include:

• Analyze the current and forecast market size of NGS sample preparation in terms of value (US$). Also, analyze the current and forecast market size of different segments and sub-segments
• Segments in the study include areas of technology, library preparation, product, application, and end-users
• Define and analysis of the regulatory framework for the NGS sample preparation industry
• Analyze the value chain involved with the presence of various intermediaries, along with analyzing customer and competitor behaviors of the industry
• Analyze the current and forecast market size of the NGS sample preparation market for the major region
• Major regions studied in the report include North America, Europe, Asia-Pacific and Rest of the world
• Company profiles of the NGS sample preparation market and the growth strategies adopted by the market players to sustain in the fast-growing market
• Deep dive regional level analysis of the industry